The Corporation elects a Mayor who along with a Deputy Mayor heads the organization. He carries out the activities through various committees such as the Standing Committee, health and sanitation committee, education committee, water works, public works, public health and market committee.

The administrative head of the Corporation is the Municipal Commissioner, who along with the Deputy Municipal Commissioners, carries out various activities related to engineering, health and sanitation, taxation and its recovery. Various departments such as public relations, library, health, finance, buildings, slums, roads, street lighting, traffic, establishment, gardens, public works, local audit, legal services, water works, education, octroi and fire services manage their specific activities. The activities of NMC are administered by its zonal offices.

There are 10 zonal offices in Nagpur – Laxmi Nagar, Dharampeth, Hanuman Nagar, Dhantoli, Nehru Nagar, Gandhi Baugh, Sataranjipura, Lakkadganj, Ashi Nagar and Mangalwari.